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Welcome to PHARMNBIOFUEL.COM,
my personal website, devoted to process development in the pharmaceutical and biofuel industry. It has been my experience that process development has been an integral part in achieving commercial viability of the manufacture of any drug or providing the first kilogram of fuel for the first vehicle road-test. Process development helps bridge the "gap" between what can happen in a small flask or plate well to what is achievable in a 50 L, 100 L, 1000 L gallon reactor and beyond. That is, not to say that, the process development associate does not require his/her share of support from his/her fellow colleagues, such as microbiologists, engineers, analytical chemists, etc. Typically, I would have to agree that pharmaceuticals and biofuels might not have too much in common, had I not worked in both industries. With the experience that I had attained in pharmaceuticals, I have developed an appreciation for practices that led to "greener" practices that were more environmentally-sound, cost-effective, and less wasteful. Now this appreciation can take many forms, of which, I will just cover a few. Research into using ionic liquids, enzymatic biotransformations, using biological feedstocks are just skimming the surface on what I think will be burgeoning areas of growth. It was my interest in the use of enzymes in industrial applications and the ease of what Nature could do that conventional chemistry could not, that intrigued me to diversify my career by gaining experience in the biofuels field.
PHARMNBIOFUEL.COM does encompass a large body of research in both the pharmaceutical and biofuel areas. Although process development is the main focus, it has fairly large breadth and inevitably, does manage to intermingle with other areas of interest:
| Analytical development seems essential when one is talking about a new process, using an in-situ technique or examining the material at the end to determine if the process needs further development, determining reaction completion, the chemical kinetics of the system and/or the reaction profile (the number of side-products and/or impurities being formed). Additionally, it can be used to help determine the suitability of the product produced from the process based on pre-existing criteria or can be used to set the quality criteria, such as purity determination, recrystallization & polymorph studies among other criteria. |
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Where organic chemistry is evolving to provide new reactions, reagents or solvents; this is something that PHARMNBIOFUEL hopes to cover. As traditional organic chemistry crosses over to using Nature to help produce molecules of revelance through the use of enzymes or other biological entities, this is also of interest. Biofuels and bioindustrials benefit from this synergy with Nature and this emerging research topic is something that is worthy of reporting. |
| Catalysis is an important aspect when talking about commonality between pharmaceuticals and biofuels, especially when one is talking about enzymatic catalysis effecting a biotransformation or when it is crucial to the process such as in saccharification. From traditional chemical catalysis to the use of enzymatic systems, they are affected some of the same factors. Whether it may be a mass-transfer issue that is solved using a different base, different vessel type or a certain mode of stirring, these are the issues that concerns the process chemist and PHARMBIOFUEL. |
